{{cart_num}}
My CartCAS：23110-15-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to light yellow Solid
Qty：
Size：
| CAS | 23110-15-8 |
| Name | Fumagillin |
| Molecular Formula | C26H34O7 |
| Molecular Weight | 458.54 |
| Solubility | Soluble in DMSO(Need ultrasonic) |
| Purity | ≥98% |
| Appearance | White to light yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 245-433-8 |
| MDL | MFCD03990453 |
| SMILES | CC(=CCC1C(O1)(C)C2C(C(CCC23CO3)OC(=O)C=CC=CC=CC=CC(=O)O)OC)C |
| InChIKey | NGGMYCMLYOUNGM-CSDLUJIJSA-N |
| InChI | InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3，33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13，19-20，23-24H，14-17H2，1-4H3，(H，27，28)/b7-5+，8-6+，11-9+，12-10+/t19-，20-，23-，24-，25+，26+/m1/s1 |
| PubChem CID | 6917655 |
| Target Point | Antibiotic |
| Passage | Anti-infection |
| Background | It is an antibiotic and a selective and effective irreversible inhibitor of MetAP2 (MetAP2). |
| Biological Activity | Fumagillin 是一种选择性且有效的甲硫氨酸胺基肽酶2(MetAP2)不可逆抑制剂，用作抗生素治疗微孢子虫病。[1] |
| In Vitro | 烟曲霉素能选择性地抑制体内的 S. cerevisiae MetAP-2 蛋白，这种结合具有高度特异性。[1]烟曲霉素不仅能逆转 Vpr 在酵母和人类细胞中的生长抑制活性，还能抑制人类巨噬细胞感染 Vpr 依赖性病毒基因的表达。[3]虽然fumagillin的毒性限制了其对人类的使用，它的类似物具有与其血管生成性能相关的结构活性关系，也许可以进一步用于探索血管生成依赖性疾病的治疗。[4] |
| In Vivo | 烟曲霉素能有效抑制大鼠体内肝脏肿瘤的生长和转移，抑制烟曲酶诱导的 MetAP-2 的表达，MetAP-2 在内皮细胞增殖中发挥着重要作用。抑制 MetAP-2 还可抑制 Bcl-2 和端粒酶的活性。[2] |
| Animal Experiment | 将成年雄性 LEW/SsN 大鼠分为 3 组，每组 25 只： 将成年雄性 LEW/SsN 大鼠分为 3 组，每组 25 只。A 组为对照组。给 B 组和 C 组大鼠服用 5 毫克/千克/天的二乙基亚硝胺。此外，C 组大鼠腹腔注射 30 毫克/(千克 x 天)烟曲霉毒素。每组 5 只大鼠分别于第 6、12、18、20 和 24 周处死，以评估 HCC 的发展和转移情况。在每个阶段测量大鼠的体重、肝脏肿瘤和受 HCC 影响的器官数量。[2] |
| Data Literature Source | [1]. Sin N，et al. The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase，MetAP-2. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6099-103. [2]. Sheen IS，et al. Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis. World J Gastroenterol. 2005 Feb 14;11(6):771-7. [3]. Watanabe N，et al. Fumagillin suppresses HIV-1 infection of macrophages through the inhibition of Vpr activity. FEBS Lett. 2006 May 15;580(11):2598-602. [4]. van den Heever JP，et al. Fumagillin: an overview of recent scientific advances and their significance for apiculture. J Agric Food Chem. 2014 Apr 2;62(13):2728-37. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Manual Download
