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My CartCAS：1009119-65-6
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 1009119-65-6 |
| Name | Daclatasvir Dihydrochloride |
| Molecular Formula | C40H52Cl2N8O6 |
| Molecular Weight | 811.8 |
| Solubility | Soluble in Water/DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD25541736 |
| SMILES | CC(C)[C@@H](C(=O)N1CCC[C@H]1C2=NC=C(N2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)[C@H](C(C)C)NC(=O)OC)NC(=O)OC.Cl.Cl |
| InChIKey | BVZLLUDATICXCI-JMSCDMLISA-N |
| InChI | InChI=1S/C40H50N8O6.2ClH/c1-23(2)33(45-39(51)53-5)37(49)47-19-7-9-31(47)35-41-21-29(43-35)27-15-11-25(12-16-27)26-13-17-28(18-14-26)30-22-42-36(44-30)32-10-8-20-48(32)38(50)34(24(3)4)46-40(52)54-6;;/h11-18，21-24，31-34H，7-10，19-20H2，1-6H3，(H，41，43)(H，42，44)(H，45，51)(H，46，52);2*1H/t31-，32-，33-，34-;;/m0../s1 |
| PubChem CID | 25154713 |
| Target Point | HCV |
| Passage | Anti-infection |
| Background | It is a highly selective inhibitor of HCV NS5A. |
| Biological Activity | Daclatasvir dihydrochloride 是一种强效口服活性 HCV NS5A 蛋白抑制剂，对多种 HCV 复制基因型的 EC50s 为 9-146 pM。达卡他韦二盐酸盐也是一种有机阴离子转运多肽 1B（OATP1B）和 OATP1B3 抑制剂，IC50 分别为 1.5 μM 和 3.27 μM。[1-3] |
| IC50 | OATP1B: 1.5μM(IC50);OATP1B3: 3.27μM(IC50)[1] |
| In Vitro | BMS-790052(100 pM或1 nM)改变NS5A的亚细胞定位和生化结构。[3]BMS-790052 对含有 HCV 基因型-4 NS5A 基因的混合复制子的抑制作用，其 50% 有效浓度(EC(50)s)范围为 7 至 13 pM。 NS5A残基30是杂交复制子对BMS-790052产生耐药性的重要部位。[4] |
| In Vivo | 慢性HCV感染患者的I期临床试验，基因型1b病毒感染患者中，单次给予100 mg剂量的达卡他韦二盐酸盐(BMS-790052)与24小时后测量的平均病毒载量减少3.3 log(10)相关，持续减少了120小时。[2] |
| Data Literature Source | [1]. Furihata T，et al. Different interaction profiles of direct-acting anti-hepatitis C virus agents with human organic anion transporting polypeptides. Antimicrob Agents Chemother. 2014 Aug;58(8): 4555-64. [2]. Gao M，et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294): 96-100. [3]. Lee C，et al. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. Virology. 2011 May 25;414(1): 10-8. [4]. Wang C，et al，O'Boyle DR 2nd，Gao M，Fridell RA. In vitro activity of BMS-790052 on hepatitis C virus genotype 4 NS5A. Antimicrob Agents Chemother. 2012 Mar;56(3): 1588-90. |
| Unit | Bottle |
| Specification | 5mg 10mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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