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My CartCAS：130-16-5
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 130-16-5 |
| Name | Cloxiquine |
| Molecular Formula | C9H6ClNO |
| Molecular Weight | 179.6 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 204-978-1 |
| MDL | MFCD00006788 |
| SMILES | C1=CC2=C(C=CC(=C2N=C1)O)Cl |
| InChIKey | CTQMJYWDVABFRZ-UHFFFAOYSA-N |
| InChI | InChI=1S/C9H6ClNO/c10-7-3-4-8(12)9-6(7)2-1-5-11-9/h1-5，12H |
| PubChem CID | 2817 |
| Target Point | Bacterial |
| Passage | Anti-infection |
| Background | Cloxiquine is a compound with antibacterial, antifungal, anti-aging and anti-tuberculosis activities. |
| Biological Activity | Cloxiquine 具有抗菌、抗真菌和抗阿米巴病活性，可用于结核病和皮肤病的研究。 通过激活 PPARγ 抑制黑色素瘤细胞的生长和转移。[1-2] |
| In Vitro | Cloxiquine(0.5-10 μM;24 h)以剂量依赖的方式抑制B16F10和A375细胞的生长和迁移，Cloxiquine(0.5-2.5 μM;24 h)抑制B16F10细胞的糖酵解。[1] Cloxiquine(cloxyquin)具有抗结核活性，对9种标准菌株和150种结核分枝杆菌的mic范围为0.062至0.25 μg/mL。[2] |
| In Vivo | Cloxiquin(5- 25mg /kg);在小鼠B16F10黑色素瘤异种移植模型中，每日1次，连续8 d，可抑制肿瘤生长和转移[1]。 |
| Data Literature Source | [1]. Zhang W，et al. Cloxiquine，a traditional antituberculosis agent，suppresses the growth and metastasis of melanoma cells through activation of PPARγ. Cell Death Dis. 2019 May 28;10(6): 404. [2]. Hongmanee P，et al. In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2007 Mar;51(3): 1105-6. |
| Unit | Bottle |
| Specification | 100mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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