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My CartCAS：57808-65-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 57808-65-8 |
| Name | Closantel |
| Molecular Formula | C22H14Cl2I2N2O2 |
| Molecular Weight | 663.07 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 260-967-1 |
| MDL | MFCD00661151 |
| SMILES | CC1=CC(=C(C=C1NC(=O)C2=C(C(=CC(=C2)I)I)O)Cl)C(C#N)C3=CC=C(C=C3)Cl |
| InChIKey | JMPFSEBWVLAJKM-UHFFFAOYSA-N |
| InChI | InChI=1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9，17，29H，1H3，(H，28，30) |
| PubChem CID | 42574 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | Closantel is a compound with potent antiparasitic activity. Closantel is a potent and highly specific inhibitor of onchocernia chitinase (OvCHT1). |
| Biological Activity | Closantel Sodium 是一种具有有效抗寄生虫活性的卤化水杨酸苯胺。是一种高效、高特异性的Onchocerca volvulus chitinase (OvCHT1)抑制剂，IC50为1.6 μM，Ki为468 nM。[1] |
| In Vitro | 用组氨酸激酶抑制剂 closantel 预处理无宿主细胞的 E. chaffeensis 或 A. phagocytophilum，可完全阻断宿主细胞的感染。[1]在 50 微克/毫升的浓度下，氯氰碘柳胺会使肝脏法氏囊病菌的活动先受到刺激，然后受到抑制，伴随着肌肉张力的增加，并在 2 小时内导致痉挛性瘫痪。 在较低浓度下瘫痪的发生可能更快。[2] |
| In Vivo | 在相同时间使用氯氰碘柳胺(7.5 毫克/千克)对线虫非常有效，但对三代线虫无效；25% 的羔羊因严重的三代线虫病。 同时使用广谱驱虫药和氯氰柳胺对这两种寄生虫都有效；没有羔羊需要停药，而且羔羊的体重增加率高于只使用广谱驱虫药或氯氰柳胺的羔羊。[5] |
| Data Literature Source | [1]. Hlasta DJ，et al. Novel inhibitors of bacterial two-component systems with gram positive antibacterial activity: pharmacophore identification based on the screening hit closantel. Bioorg Med Chem Lett. 1998 Jul 21;8(14): 1923-8. [2]. Cheng Z，et al. Intra-leukocyte expression of two-component systems in Ehrlichia chaffeensis and Anaplasma phagocytophilum and effects of the histidine kinase inhibitor closantel. Cell Microbiol. 2006 Aug;8(8): 1241-52. [3]. Skuce PJ，et al The effect of the hydrogen ionophore closantel upon the pharmacology and ultrastructure of the adult liver fluke Fasciola hepatica. Parasitol Res. 1990;76(3): 241-50. [4]. Dash KM. Control of helminthosis in lambs by strategic treatment with closantel and broad-spectrum anthelmintics. Aust Vet J. 1986 Jan;63(1): 4-7. [5]. Rothwell J，et al Haemonchus contortus: the uptake and metabolism of closantel. Int J Parasitol. 1997 Mar;27(3): 313-9. [6]. Garner AL，et al Design，synthesis，and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9;54(11): 3963-72. |
| Unit | Bottle |
| Specification | 100mg 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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