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My CartCAS：60200-06-8
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
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| CAS | 60200-06-8 |
| Name | Clorsulon |
| Molecular Formula | C8H8Cl3N3O4S2 |
| Molecular Weight | 380.66 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 262-100-2 |
| MDL | MFCD00072006 |
| SMILES | C1=C(C(=CC(=C1N)S(=O)(=O)N)S(=O)(=O)N)C(=C(Cl)Cl)Cl |
| InChIKey | QOVTVIYTBRHADL-UHFFFAOYSA-N |
| InChI | InChI=1S/C8H8Cl3N3O4S2/c9-7(8(10)11)3-1-4(12)6(20(14，17)18)2-5(3)19(13，15)16/h1-2H，12H2，(H2，13，15，16)(H2，14，17，18) |
| PubChem CID | 43231 |
| Target Point | Parasite |
| Passage | Anti-infection |
| Background | It is a compound with antiparasitic activity. |
| Biological Activity | Clorsulon 是一种口服有效的杀虫剂，是3-磷酸甘油酸和ATP的竞争性抑制剂，Ki值为0.29 mM。[1-2] |
| In Vivo | A single dose of 15 mg/kg was effective in removing over 90% of immature Fasciola hepatica from sheep(6 weeks after infection)and calves(8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature(16 weeks old)liver fluke from sheep. Single oral doses up to 400 mg/kg were tolerated by sheep without gross toxic symptoms.[1] When cultured in vivo，Clorsulon severely damages the cortex and internal organs of the liver fluke.[3] |
| Animal Experiment | Male Sprague-Dawley rats infected with F. hepatica were dosed orally at 8-8.5 weeks post-infection with clorsulon at a concentration of 12.5 mg/kg body weight. After 24，48 and 72 h，rats were sacrificed by cervical dislocation and mature flukes recovered from the bile ducts.[3] |
| Data Literature Source | [1]. Mrozik H，et al. 4-amino-6-(trichloroethenyl)-1，3-benzenedisulfonamide，a new，potent fasciolicide. J Med Chem. 1977 Sep;20(9): 1225-7. [2]. Schulman MD，et al. Mechanism of action of MK-401 against Fasciola hepatica: inhibition of phosphoglycerate kinase. Mol Biochem Parasitol. 1982 Mar;5(3): 133-45. [3]. Meaney M，et al. Transmission electron microscope study of the ultrastructural changes induced in the tegument and gut of Fasciola hepatica following in vivo drug treatment with clorsulon. Parasitol Res. 2004 Feb;92(3): 232-41. |
| Unit | Bottle |
| Specification | 250mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
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