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My CartCAS：161796-78-7
Storage：Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
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| CAS | 161796-78-7 |
| Name | Esomeprazole Sodium |
| Molecular Formula | C17H18N3NaO3S |
| Molecular Weight | 367.4 |
| Solubility | Soluble in DMSO ≥5mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:-20℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD07802816 |
| SMILES | CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C([N-]2)C=C(C=C3)OC.[Na+] |
| InChIKey | RYXPMWYHEBGTRV-JIDHJSLPSA-N |
| InChI | InChI=1S/C17H18N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17;/h5-8H，9H2，1-4H3;/q-1;+1/t24-;/m0./s1 |
| PubChem CID | 46853837 |
| Target Point | Proton Pump |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is an effective proton pump inhibitor, which can reduce acid secretion by inhibiting H+/K+ ATPase in gastric parietal cells. |
| Biological Activity | Esomeprazole Sodium是一种强效口服活性质子泵抑制剂。通过抑制胃顶叶细胞中的 H+、K+-ATPase 减少胃酸分泌，是一种外泌体抑制剂，通过抑制 V-H+-ATP 酶阻断外泌体的释放，具有对症治疗胃食管反流病的研究潜力。[1-4] |
| In Vitro | 埃索美拉唑通过增加细胞内酸化，以剂量依赖的方式抑制体外三阴性乳腺癌细胞的生长；埃索美拉唑对非癌乳腺上皮 MCF-10A 细胞没有明显影响，在乳腺癌治疗中辅助使用埃索美拉唑可消除多柔比星的不良反应并提高疗效。[1]埃索美拉唑镁 40 毫克，每天一次，与阿莫西林和克拉霉素合用可有效根除幽门螺杆菌感染。[3] |
| In Vivo | 在有埃索美拉唑或没有埃索美拉唑治疗的情况下，动物暴露于棉花烟雾中 3 周。我们发现，与对照组相比，治疗性服用埃索美拉唑能显著抑制该组动物肺部纤维化的进展。此外，埃索美拉唑还降低了循环中的炎症和纤维化标志物。[2] |
| Data Literature Source | [1]. Goh W，et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17(3): 439-46. [2]. Nelson C，et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8: 16. [3]. Johnson TJ，Hedge DD. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59(14): 1333-9. [4]. Zhang H，et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1): 1322-1330. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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