{{cart_num}}
My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > Membrane Transporter & Ion Channel > Dronedarone HydrochlorideCAS：141625-93-6
Molecular Formula：C31H45ClN2O5S
Molecular Weight：593.22
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
Size：
| CAS | 141625-93-6 |
| Name | Dronedarone Hydrochloride |
| Molecular Formula | C31H45ClN2O5S |
| Molecular Weight | 593.22 |
| Solubility | Soluble in DMSO ≥3mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD00914940 |
| SMILES | CCCCC1=C(C2=C(O1)C=CC(=C2)NS(=O)(=O)C)C(=O)C3=CC=C(C=C3)OCCCN(CCCC)CCCC.Cl |
| InChIKey | DWKVCQXJYURSIQ-UHFFFAOYSA-N |
| InChI | InChI=1S/C31H44N2O5S.ClH/c1-5-8-12-29-30(27-23-25(32-39(4，35)36)15-18-28(27)38-29)31(34)24-13-16-26(17-14-24)37-22-11-21-33(19-9-6-2)20-10-7-3;/h13-18，23，32H，5-12，19-22H2，1-4H3;1H |
| PubChem CID | 219025 |
| Target Point | Potassium Channel;Sodium Channel;Calcium Channel |
| Passage | Membrane Transporter&Ion Channel |
| Background | It is an effective blocker of ion currents, inhibiting Na+, K+ and Ca2+ currents. |
| Biological Activity | Dronedarone Hydrochloride是一种非碘化胺酮衍生物，可抑制 Na+、K+ 和 Ca2+ 电流。用于治疗阵发性和持续性房颤或房扑的患者。[1-4] |
| In Vitro | 应用膜片钳技术研究了离体豚鼠心室肌细胞快速Na(+)和Ca(2+)电流以及中国仓鼠卵巢(CHO)细胞表达的人HCN4通道。在豚鼠心室肌细胞中，当保持电位(V(hold))为-80 mV时，dronedarone 对快速Na(+)通道电流表现出状态依赖性抑制，IC(50)为0.7±0.1 μM。在CHO细胞中表达的人HCN4通道被dronedarone阻断，其IC(50)为1.0±0.1 μM。dronedarone对快速Na(+)和Ca(2+)通道的抑制取决于细胞的静息膜电位(状态依赖性阻滞)，有利于心房选择性作用模式。除了快速的Na(+)和Ca(2+)通道外，dronedarone也抑制HCN4电流。[1] 在豚鼠心室肌细胞中，当保持电位为- 80 mV时，dronedarone对快速Na+通道电流表现出状态依赖性抑制，IC50为0.7±0.1 μM。[2] |
| In Vivo | Dronedarone Hydrochloride在 3 毫克/千克静脉注射时可将心室颤动(VF)的发生率从 80% 显著降至 30%(p < 0.05)，在 10 毫克/千克静脉注射时可消除 VF 并降低死亡率。[3] Dronedarone Hydrochloride可抑制体内颈动脉血栓形成。经屈奈达隆处理的小鼠凝血酶和胶原诱导的血小板聚集功能受损(P/0.05)，动脉壁中纤维蛋白溶解系统的抑制剂--胰蛋白酶原激活物抑制剂-1(PAI1)的表达减少。[4] |
| Data Literature Source | [1]. Bogdan R，Goegelein H，Ruetten H. Effect of dronedarone on Na+，Ca2+ and HCN channels. Naunyn Schmiedebergs Arch Pharmacol. 2011 Apr;383(4): 347-56. doi: 10.1007/s00210-011-0599-9. Epub 2011 Jan 29. [2]. Doggrell SA，Hancox JC. Dronedarone: an amiodarone analogue. Expert Opin Investig Drugs. 2004 Apr;13(4): 415-26. doi: 10.1517/13543784.13.4.415. [3]. Manning AS，et al. SR 33589，a new amiodarone-like agent: effect on ischemia- and reperfusion-induced arrhythmias in anesthetized rats. J Cardiovasc Pharmacol. 1995 Sep;26(3): 453-61. [4]. Breitenstein A，et al. Dronedarone reduces arterial thrombus formation. Basic Res Cardiol. 2012 Nov;107(6): 302. doi: 10.1007/s00395-012-0302-4. Epub 2012 Sep 29. |
| Unit | Bottle |
| Specification | 5mg |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Sorry, there is no more information.
Sorry, there is no more information.
Manual Download
