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My CartCAS：1821-12-1
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：White to off-white Solid
Qty：
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| CAS | 1821-12-1 |
| Name | 4-Phenylbutyric Acid |
| Molecular Formula | C10H12O2 |
| Molecular Weight | 164.2 |
| Solubility | Soluble in DMSO ≥200mg/mL |
| Purity | ≥98% |
| Appearance | White to off-white Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| EC | EINECS 217-341-8 |
| MDL | MFCD00004403 |
| SMILES | C1=CC=C(C=C1)CCCC(=O)O |
| InChIKey | OBKXEAXTFZPCHS-UHFFFAOYSA-N |
| InChI | InChI=1S/C10H12O2/c11-10(12)8-4-7-9-5-2-1-3-6-9/h1-3，5-6H，4，7-8H2，(H，11，12) |
| PubChem CID | 4775 |
| Target Point | HDAC;ER Stress inhibitor |
| Passage | DNA Damage/DNA Repair;Epigenetics;NF-κB;ER Stress |
| Background | B4-Phenylbutyric Acid is a histone deacetylase (HDAC) and endoplasmic reticulum stress (ER) inhibitor. |
| Unit | Bottle |
| Specification | 100mg |
Examples of using this product（for reference only）
In Vitro:
Cell（human hepatoma cell line (HepG2)；0~5mM 4-PBA；4d）:
To explore whether RD-induced apoptosis was mediated by ER stress, we constructed a cell model of the inhibition of ER stress. 4-phenyl butyric acid (4-PBA), an ER stress inhibitor, was purchased from Solarbio. It was added into the Rf medium at dosages of 0, 0.5, 2.5, and 5 mM. The cells were cultured in the above medium for 4 d for the ER stress-suppression assay and were subjected to subsequent apoptosis analyses.
Reference：
Zhang B, Cao JT, Wu YB, Gao KX, Xie M, Zhou ZK, Tang J, Hou SS. Riboflavin (Vitamin B2) Deficiency Induces Apoptosis Mediated by Endoplasmic Reticulum Stress and the CHOP Pathway in HepG2 Cells. Nutrients. 2022 Aug 16;14(16):3356. doi: 10.3390/nu14163356. PMID: 36014863; PMCID: PMC9414855.
In Vivo:
Rats ( Sprague-Dawley (SD) rats; 5 mg/kg body weight 4-PBA, 28 days):
Twenty SD rats were randomly divided into 4 groups(n = 5 per group): the control group (no periodontitis,G1), the experimental periodontitis group (ligature +LPS, G2), the LIPUS treatment group (ligature + LPS +LIPUS, G3), and the 4-PBA treatment group (ligature +LPS + 4-PBA, G4). General anesthesia was injected intraperitoneally with 10% chloral hydrate (5 mL/kg), and surgery was performed by two investigators. The gingiva of the maxillary first molar was separated with a dental probe, and then the 0.020 stainless steel ligature was inserted into the distal side and ring the maxillary first molar, and the ligature needs to be tied tightly. 0.1 ml LPS (10μg/ml) was injected at 48-h intervals, 4 times in total. After induction of periodontitis, G3 received treatment of LIPUS (90 mW/cm2, 1.5 mHz,30 min) for 28 days, and G4 was fed with 4-PBA solution at a final concentration of 5 mg/kg body weight through drinking water for 28 days. Eight weeks after the induction of periodontitis, the rats (n = 5 per group) were euthanized and samples were obtained for further experimental analyses.
Reference：
Li H, Deng Y, Tan M, Feng G, Kuang Y, Li J, Song J. Low-intensity pulsed ultrasound upregulates osteogenesis under inflammatory conditions in periodontal ligament stem cells through unfolded protein response. Stem Cell Res Ther. 2020 Jun 3;11(1):215. doi: 10.1186/s13287-020-01732-5. PMID: 32493507.
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
Note：
1. The products are all for scientific research use only. Do not use it for medical, clinical diagnosis or treatment, food and cosmetics, etc. Do not store them in ordinary residential areas.
2. For your safety and health, please wear laboratory clothes, disposable gloves and masks.
3. The experimental results may be affected by many factors, after-sale service is limited to the product itself and does not involve other compensation.
Li H, et al. Stem Cell Res Ther. 2020 Jun 3;11(1):215.
Li H, et al. Stem Cell Res Ther. 2020 Jun 3;11(1):215.
Li H, et al. Stem Cell Res Ther. 2020 Jun 3;11(1):215.
Zhang B, et al.Nutrients. 2022 Aug 16;14(16)3356.
Zhang B, et al.Nutrients. 2022 Aug 16;14(16)3356.
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