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My Cart> Small Molecule Compounds > Inhibitors & Antagonists & Agonists > PI3K/Akt/mTOR > Dorsomorphin dihydrochlorideCAS：1219168-18-9
Molecular Formula：C24H25N5O·2HCl
Molecular Weight：472.41
Storage：Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year
Purity：≥98%
Appearance：Light yellow to yellow Solid
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| CAS | 1219168-18-9 |
| Name | Dorsomorphin dihydrochloride |
| Molecular Formula | C24H25N5O·2HCl |
| Molecular Weight | 472.41 |
| Solubility | Soluble in Water |
| Purity | ≥98% |
| Appearance | Light yellow to yellow Solid |
| Storage | Powder:2-8℃，2 years;Insolvent(Mother Liquid):-20℃，6 months;-80℃，1 year |
| MDL | MFCD11112197 |
| SMILES | [H]Cl.[H]Cl.C12=C(C3=CC=NC=C3)C=NN1C=C(C4=CC=C(OCCN5CCCCC5)C=C4)C=N2 |
| InChIKey | RJDVIJJQKMGPMV-UHFFFAOYSA-N |
| InChI | InChI=1S/C24H25N5O.2ClH/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20;;/h4-11,16-18H,1-3,12-15H2;2*1H |
| PubChem CID | 49761481 |
| Target Point | AMPK |
| Passage | PI3K/Akt/mTOR;Epigenetics |
| Background | Dorsomorphin Dihydrochloride is a potent, selective and ATP-competitive AMPK inhibitor. |
| Biological Activity | Dorsomorphin dihydrochloride是一种有效，选择性和 ATP 竞争性的 AMPK 抑制剂，Ki 为109±16 nM。[1-4] |
| Data Literature Source | [1]. Zhou G， et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest. 2001 Oct; 108 (8) :1167-74. [2]. Saito S， et al. Compound C prevents the unfolded protein response during glucose deprivation through a mechanism independent of AMPK and BMP signaling. PLoS One. 2012; 7 (9) :e45845. [3]. Yu PB， et al. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan; 4 (1) :33-41. [4]. Zhang DY， et al. Role of autophagy and its molecular mechanisms in mice intestinal tract after severe burn. J Trauma Acute Care Surg. 2017 Oct; 83 (4) :716-724 |
| Unit | Piece |
| Specification | 5mg 10mM*1mL in Water |
Remark：These protocols are for reference only. Solarbio does not independently validate these methods.
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Novel anti-obesity peptide (RLLPH) derived from hazelnut (Corylus heterophylla Fisch) protein hydrolysates inhibits adipogenesis in 3T3-L1 adipocytes by regulating adipogenic transcription factors and adenosine monophosphate-activated protein kinase (AMPK
Click to check >>Author：Wang J; Zhou M; Wu T; Fang L; Liu C; Min W.
IF：2.8000
Publish_to：J Biosci Bioeng
PMID：31630942
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