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Anti-HLA-DOB Polyclonal Antibody - SAlexa Fluor 640
Cat: K109024P - SAlexa Fluor 640
Summary:
【Product name】:Anti-HLA-DOB Polyclonal Antibody - SAlexa Fluor 640 【Source】:Rabbit
【Isotype】:IgG 【Purification】:Affinity purification
【Gene ID】:3112 【Swiss Prot】:P13765
【Tested applications】:WB,IHC
【Recommended dilution】:WB 1:1000-3000. IHC 1:50-200.
【Immunogen】:Recombinant protein of human HLA-DOB
【Public Immunogen Range】:1-273aa
【Storage】:Store at -20℃. Avoid freeze/thaw cycles.
Background:
HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.
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