Anti-Caspase-1 P10 Polyclonal Antibody - Cy5.5
Cat: K011560P - Cy5.5
Summary:
| 【Product name】：Anti-Caspase-1 P10 Polyclonal Antibody - Cy5.5 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：834 | 【Swiss Prot】：P29466 |
| 【Observed】：45kDa | |
| 【Tested applications】：FC ICC IF | |
| 【Recommended dilution】：Flow-Cyt 1:50-200. ICC 1:50-200. IF 1:50-200 | |
| 【Immunogen】：A synthetic peptide of human Caspase-1 P10 | |
| 【Public Immunogen Range】：321-404aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins， such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD)， into active mature peptides (PubMed:15326478， PubMed:15498465， PubMed:1574116， PubMed:26375003， PubMed:32051255， PubMed:37993714， PubMed:7876192， PubMed:9334240). Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex， it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18， releasing the mature cytokines which are involved in a variety of inflammatory processes (PubMed:15326478， PubMed:15498465， PubMed:1574116， PubMed:32051255， PubMed:7876192).
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