Anti-CLCN2 Polyclonal Antibody - HRP
Cat: K116474P - HRP
Summary:
| 【Product name】：Anti-CLCN2 Polyclonal Antibody - HRP | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：1181 | 【Swiss Prot】：P51788 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：WB 1:500-2000. ELISA 1:100-1000. IHC 1:20-200. ICC 1:50-200 | |
| 【Immunogen】：Recombinant protein of human CLCN2 | |
| 【Public Immunogen Range】：171-388aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume， membrane potential stabilization， signal transduction and transepithelial transport. Involved in the regulation of aldosterone production. The opening of CLCN2 channels at hyperpolarized membrane potentials in the glomerulosa causes cell membrane depolarization， activation of voltage-gated Ca2+ channels and increased expression of aldosterone synthase， the rate-limiting enzyme for aldosterone biosynthesis (PubMed:29403011， PubMed:29403012).
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