Anti-PABIR1 Polyclonal Antibody - SAlexa Fluor 680
Cat: K116465P - SAlexa Fluor 680
Summary:
| 【Product name】：Anti-PABIR1 Polyclonal Antibody - SAlexa Fluor 680 | 【Source】：Rabbit |
| 【Isotype】：IgG | 【Purification】：Affinity purification |
| 【Gene ID】：116224 | 【Swiss Prot】：Q96E09 |
| 【Tested applications】：IHC | |
| 【Recommended dilution】：IHC 1:50-200. | |
| 【Immunogen】：Recombinant protein of human PABIR1 | |
| 【Public Immunogen Range】：31-278aa | |
| 【Storage】：Store at -20℃. Avoid freeze / thaw cycles. | |
Background:
Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481， PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1， promoting ubiquitin-mediated proteolysis of WEE1， thereby releasing G2/M checkpoint (PubMed:33108758).
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