Enables several functions， including actin binding activity; phosphatidylinositol-3，4，5-trisphosphate binding activity; and type I transforming growth factor beta receptor binding activity. Involved in several processes， including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of cellular component biogenesis. Acts upstream of or within cell adhesion and protein localization to cell junction. Located in cytosol; focal adhesion; and nucleoplasm. Is extrinsic component of cytoplasmic side of plasma membrane. Part of adherens junction and plasma membrane. Biomarker of acute myeloid leukemia.